In the open marketplaces found in cities and villages throughout Africa, women traders usually predominate. This gives women considerable weight as economic actors, because these marketplace systems are the primary distributive networks in most parts of Africa. A large proportion of Africa’s consumer goods and foodstuffs move through their intricate chains of intermediaries, which can include market retailers, neighborhood shops, street vendors, wholesalers, and travelers who collect goods from farms, factories, and ports. Although the vast majority of women traders live at or below the poverty line, some have risen to powerful positions that earn them the sobriquet of queen. Different regions of Africa show distinctive patterns of trading practices and of men and women’s participation in specific trading roles, reflecting specific gendered histories of precolonial trade, colonial interventions, and waves of national policy. These variations arise not from some primordial isolation, but from traders’ varied positioning within longstanding trade relations that have linked Africans since ancient times between regions, across the Sahara Desert and over adjoining oceans. Women’s trading roles are more highly developed in western Africa than in eastern, northern, and southern Africa, where precolonial trading patterns were more radically disrupted by conquest, land appropriation, and apartheid. Ideologies and arenas of practice such as Islam, Christianity, modernization, socialism, structural adjustment, and globalization likewise shape the constraints and opportunities facing women traders in any given situation. Because these influences operate around the globe, though not uniformly, they to some extent create parallel or convergent trends in widely separated nations. Deepening economic pressures today push even more women and men into trading to support their families and sustain the hope of prosperity. Market women struggle individually and collectively to keep their communities going under difficult circumstances that make formal economic channels function poorly. Their determined efforts give African economies more resilience as they respond to the challenges of war, political instability, and climate change.