The European invasion of the continent to which we now refer as North America unfolded in several different ways, each with its own particular implications. Yet no matter their differences, each colonial effort drew upon the same moral, intellectual, and material premises necessary to justify and enact the dispossession of the land’s first peoples. From religious arguments about Christianity extirpating “savage devils” from New England or Jamestowners’ obsession with finding gold and precious minerals to the introduction of new species of plants and animals across the continent and imperial assertions of sovereignty, the European invasion of America touched every facet of the lives that had brought first peoples and colonizers together. Examining how first peoples represented their land and how European invaders and their later American successors countered such mapping practices with their own cartographical projections affords an important way to understand a centuries-long process of place-making and place-taking too often glossed as colonization.