Africans and their descendants enslaved in the western hemisphere resisted their status in several ways. One of the most consequential methods was self-liberation. While many date the Underground Railroad as starting in the 1830s, when railroad terminology became common, enslaved people began escaping from the earliest colonial period. Allies assisted in journeys to freedom, but the Underground Railroad is centered around the enslaved people who resisted their status and asserted their humanity. Fugitives exhibited creativity, determination, courage, and fortitude in their bids for freedom. Together with their allies—white, Black, and Native American—they represented a grassroots resistance movement in which people united across racial, gender, religious, and class lines in hopes of promoting social change. While some participation was serendipitous and fleeting, the Underground Railroad operated through local and regional networks built on trusted circles of extended families and faith communities. These networks ebbed and flowed over time and space. At its root, the Underground Railroad was both a migration story and a resistance movement. African Americans were key participants in this work as self-liberators and as operators helping others to freedom. Their quest for freedom extended to all parts of what became the United States and internationally to Canada, Mexico, Caribbean nations, and beyond.