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Chemical and biological weapons represent two distinct types of munitions that share some common policy implications. While chemical weapons and biological weapons are different in terms of their development, manufacture, use, and the methods necessary to defend against them, they are commonly united in matters of policy as “weapons of mass destruction,” along with nuclear and radiological weapons. Both chemical and biological weapons have the potential to cause mass casualties, require some technical expertise to produce, and can be employed effectively by both nation states and non-state actors. U.S. policies in the early 20th century were informed by preexisting taboos against poison weapons and the American Expeditionary Forces’ experiences during World War I. The United States promoted restrictions in the use of chemical and biological weapons through World War II, but increased research and development work at the outset of the Cold War. In response to domestic and international pressures during the Vietnam War, the United States drastically curtailed its chemical and biological weapons programs and began supporting international arms control efforts such as the Biological and Toxin Weapons Convention and the Chemical Weapons Convention. U.S. chemical and biological weapons policies significantly influence U.S. policies in the Middle East and the fight against terrorism.

The development of military arms harnessing nuclear energy for mass destruction has inspired continual efforts to control them. Since 1945, the United States, the Soviet Union, the United Kingdom, France, the People’s Republic of China (PRC), Israel, India, Pakistan, North Korea, and South Africa acquired control over these powerful weapons, though Pretoria dismantled its small cache in 1989 and Russia inherited the Soviet arsenal in 1996. Throughout this period, Washington sought to limit its nuclear forces in tandem with those of Moscow, prevent new states from fielding them, discourage their military use, and even permit their eventual abolition. Scholars disagree about what explains the United States’ distinct approach to nuclear arms control. The history of U.S. nuclear policy treats intellectual theories and cultural attitudes alongside technical advances and strategic implications. The central debate is one of structure versus agency: whether the weapons’ sheer power, or historical actors’ attitudes toward that power, drove nuclear arms control. Among those who emphasize political responsibility, there are two further disagreements: (1) the relative influence of domestic protest, culture, and politics; and (2) whether U.S. nuclear arms control aimed first at securing the peace by regulating global nuclear forces or at bolstering American influence in the world. The intensity of nuclear arms control efforts tended to rise or fall with the likelihood of nuclear war. Harry Truman’s faith in the country’s monopoly on nuclear weapons caused him to sabotage early initiatives, while Dwight Eisenhower’s belief in nuclear deterrence led in a similar direction. Fears of a U.S.-Soviet thermonuclear exchange mounted in the late 1950s, stoked by atmospheric nuclear testing and widespread radioactive fallout, which stirred protest movements and diplomatic initiatives. The spread of nuclear weapons to new states motivated U.S. presidents (John Kennedy in the vanguard) to mount a concerted campaign against “proliferation,” climaxing with the 1968 Treaty on the Non-Proliferation of Nuclear Weapons (NPT). Richard Nixon was exceptional. His reasons for signing the Strategic Arms Limitation Treaty (SALT I) and Anti-Ballistic Missile Treaty (ABM) with Moscow in 1972 were strategic: to buttress the country’s geopolitical position as U.S. armed forces withdrew from Southeast Asia. The rise of protest movements and Soviet economic difficulties after Ronald Reagan entered the Oval Office brought about two more landmark U.S.-Soviet accords—the 1987 Intermediate Ballistic Missile Treaty (INF) and the 1991 Strategic Arms Reduction Treaty (START)—the first occasions on which the superpowers eliminated nuclear weapons through treaty. The country’s attention swung to proliferation after the Soviet collapse in December 1991, as failed states, regional disputes, and non-state actors grew more prominent. Although controversies over Iraq, North Korea, and Iran’s nuclear programs have since erupted, Washington and Moscow continued to reduce their arsenals and refine their nuclear doctrines even as President Barack Obama proclaimed his support for a nuclear-free world.

The United States’ construction and operation of the Panama Canal began as an idea and developed into a reality after prolonged diplomatic machinations to acquire the rights to build the waterway. Once the canal was excavated, a century-long struggle ensued to hold it in the face of Panamanian nationalism. Washington used considerable negotiation and finally gunboat diplomacy to achieve its acquisition of the Canal. The construction of the channel proved a titanic effort with large regional, global, and cultural ramifications. The importance of the Canal as a geostrategic and economic asset was magnified during the two world wars. But rising Panamanian frustration over the U.S. creation of a state-within-a-state via the Canal Zone, one with a discriminatory racial structure, fomented a local movement to wrest control of the Canal from the Americans. The explosion of the 1964 anti-American uprising drove this process forward toward the 1977 Carter-Torrijos treaties that established a blueprint for eventual U.S. retreat and transfer of the channel to Panama at the century’s end. But before that historic handover, the Noriega crisis and the 1989 U.S. invasion nearly upended the projected transition of U.S. retreat from the management and control of the Canal. Early historians emphasized high politics, economics, and military considerations in the U.S. acquisition of the Canal. They concentrated on high-status actors, economic indices, and major political contingencies in establishing the U.S. colonial order on the isthmus. Panamanian scholars brought a legalistic and nationalist critique, stressing that Washington did not create Panama and that local voices in the historical debate have largely been ignored in the grand narrative of the Canal as a great act of progressive civilization. More recent U.S. scholarship has focused on American imperialism in Panama, on the role of race, culture, labor, and gender as major factors that shaped the U.S. presence, the structure of the Canal Zone, as well as Panamanian resistance to its occupation. The role of historical memory, of globalization, representation, and how the Canal fits into notions of U.S. empire have also figured more prominently in recent scholarly examination of this relationship. Contemporary research on the Panama Canal has been supported by numerous archives in the United States and Panama, as well as a variety of newspapers, magazines, novels, and films.

Since the social sciences began to emerge as scholarly disciplines in the last quarter of the 19th century, they have frequently offered authoritative intellectual frameworks that have justified, and even shaped, a variety of U.S. foreign policy efforts. They played an important role in U.S. imperial expansion in the late 19th and early 20th centuries. Scholars devised racialized theories of social evolution that legitimated the confinement and assimilation of Native Americans and endorsed civilizing schemes in the Philippines, Cuba, and elsewhere. As attention shifted to Europe during and after World War I, social scientists working at the behest of Woodrow Wilson attempted to engineer a “scientific peace” at Versailles. The desire to render global politics the domain of objective, neutral experts intensified during World War II and the Cold War. After 1945, the social sciences became increasingly central players in foreign affairs, offering intellectual frameworks—like modernization theory—and bureaucratic tools—like systems analysis—that shaped U.S. interventions in developing nations, guided nuclear strategy, and justified the increasing use of the U.S. military around the world. Throughout these eras, social scientists often reinforced American exceptionalism—the notion that the United States stands at the pinnacle of social and political development, and as such has a duty to spread liberty and democracy around the globe. The scholarly embrace of conventional political values was not the result of state coercion or financial co-optation; by and large social scientists and policymakers shared common American values. But other social scientists used their knowledge and intellectual authority to critique American foreign policy. The history of the relationship between social science and foreign relations offers important insights into the changing politics and ethics of expertise in American public policy.

Technology is ubiquitous in the history of US foreign relations. Throughout US history, technology has played an essential role in how a wide array of Americans have traveled to and from, learned about, understood, recorded and conveyed information about, and attempted to influence, benefit from, and exert power over other lands and peoples. The challenge for the historian is not to find where technology intersects with the history of US foreign relations, but how to place a focus on technology without falling prey to deterministic assumptions about the inevitability of the global power and influence—or lack thereof—the United States has exerted through the technology it has wielded. “Foreign relations” and “technology” are, in fact, two terms with extraordinarily broad connotations. “Foreign relations” is not synonymous with “diplomacy,” but encompasses all aspects and arenas of American engagement with the world. “Technology” is itself “an unusually slippery term,” notes prominent technology historian David Nye, and can refer to simple tools, more complex machines, and even more complicated and expansive systems on which the functionality of many other innovations depends. Furthermore, processes of technological innovation, proliferation, and patterns of use are shaped by a dizzying array of influences embedded within the larger surrounding context, including but by no means limited to politics, economics, laws, culture, international exchanges, and environment. While some of the variables that have shaped how the United States has deployed its technological capacities were indeed distinctly American, others arose outside the United States and lay beyond any American ability to control. A technology-focused rendering of US foreign relations and global ascendancy is not, therefore, a narrative of uninterrupted progress and achievement, but an accounting of both successes and failures that illuminate how surrounding contexts and decisions have variably shaped, encouraged, and limited the technology and power Americans have wielded.