American activists who challenged South African apartheid during the Cold War era extended their opposition to racial discrimination in the United States into world politics. US antiapartheid organizations worked in solidarity with forces struggling against the racist regime in South Africa and played a significant role in the global antiapartheid movement. More than four decades of organizing preceded the legislative showdown of 1986, when a bipartisan coalition in Congress overrode President Ronald Reagan’s veto, to enact economic sanctions against the apartheid regime in South Africa. Adoption of sanctions by the United States, along with transnational solidarity with the resistance to apartheid by South Africans, helped prompt the apartheid regime to relinquish power and allow the democratic elections that brought Nelson Mandela and the African National Congress to power in 1994. Drawing on the tactics, strategies and moral authority of the civil rights movement, antiapartheid campaigners mobilized public opinion while increasing African American influence in the formulation of US foreign policy. Long-lasting organizations such as the American Committee on Africa and TransAfrica called for boycotts and divestment while lobbying for economic sanctions. Utilizing tactics such as rallies, demonstrations, and nonviolent civil disobedience actions, antiapartheid activists made their voices heard on college campuses, corporate boardrooms, municipal and state governments, as well as the halls of Congress. Cultural expressions of criticism and resistance served to reinforce public sentiment against apartheid. Novels, plays, movies, and music provided a way for Americans to connect to the struggles of those suffering under apartheid. By extending the moral logic of the movement for African American civil rights, American anti-apartheid activists created a multicultural coalition that brought about institutional and governmental divestment from apartheid, prompted Congress to impose economic sanctions on South Africa, and increased the influence of African Americans regarding issues of race and American foreign policy.