The transformation of post-industrial American life in the late 20th and early 21st centuries includes several economically robust metropolitan centers that stand as new models of urban and economic life, featuring well-educated populations that engage in professional practices in education, medical care, design and legal services, and artistic and cultural production. By the early 21st century, these cities dominated the nation’s consciousness economically and culturally, standing in for the most dynamic and progressive sectors of the economy, driven by collections of technical and creative spark. The origins of these academic and knowledge centers are rooted in the political economy, including investments shaped by federal policy and philanthropic ambition. Education and health care communities were and remain frequently economically robust but also rife with racial, economic, and social inequality, and riddled with resulting political tensions over development. These information communities fundamentally incubated and directed the proceeds of the new economy, but also constrained who accessed this new mode of wealth in the knowledge economy.