“Hunter-gatherer” refers to the range of human subsistence patterns and socio-economies since the Late Pleistocene (after about 126,000 years ago), some of which are still practiced in rare pockets across the globe. Hunter-gatherer research is centered on ethnohistorical records of the lifeways, economies, and interpersonal relationships of groups who gather field and wild foods and hunt for meat. Information collected in this way is cautiously applied to the Stone Age and Paleolithic archaeological records to inform on or build hypotheses about past human behaviors. Late Pleistocene hunter-gatherers possessed the behavioral, technological, and cognitive wherewithal to populate the globe. Hunter-gatherer groups are often relatively egalitarian regarding power and gender relationships. But, as is the case for all mammals, only females bear offspring. This biological reality has socioeconomic and behavioral implications when it comes to food supply. Whereas humans share the principles of the mammalian reproductive process, only humans evolved to occupy a unique cogni-behavioral niche in which we are able to outsmart other animal competition in the quest for survival on any given landscape. Since early on in our history, women of our species gave birth to relatively large-brained offspring with considerable cognitive potential compared to that of other animals. Key to this development is the consumption of specific foods, which contain brain-selective nutrients such as omega-6 and omega-3 polyunsaturated fatty acids and trace elements including iron, iodine, copper, selenium, and zinc. Such nutrients are important for all peoples past and present. Ethnohistorical and nutritional evidence shows that edible plants and small animals, most often gathered by women, represent an abundant and accessible source of “brain foods.” This is in contrast to the “man the hunter” hypothesis where big-game hunting and meat-eating are seen as prime movers in the development of biological and behavioral traits that distinguish humans from other primates.