China and India together account for over one-third of the world’s population and both countries have considerably fewer women than men.. With long histories of skewed sex ratios and gender discrimination, these two countries have experienced a sharp decline in the birth of girls since the late 20th century. The unfolding and intimate relationship between gendered social structures, son preference, fertility decline, and new sex determination technologies has had serious demographic and social consequences, resulting in millions of “missing” girls, surplus males, bride shortages, and possibly, rising levels of gender violence. Even as women’s socio-economic indicators such as life expectancy, literacy, education, and fertility have improved, families continue to show a preference for sons raising questions between the tenuous relationship between development and gender equality. The advantages of raising sons over daughters, supported by traditional kinship, family, and marriage systems, appear to have got further entrenched in the era of neoliberal economies. Family planning policies of both nations, advocating small families, and the advent of pre-natal sex selection technologies further set the stage for the prevention of birth of daughters. Governments in both countries have since banned sex determination and launched policies and schemes to redress the gender imbalance and improve the value of the girl child. While these policies have not been highly successful, other social forces such as urbanization and rising educational levels are beginning to transform the way girls are perceived. A kernel of hope seems to be emerging at the beginning of the 21st century, as some improvement is visible in the sex ratio at birth in some of the worst affected regions in the two countries.