“Buddhist medicine” is a convenient term commonly used to refer to the many diverse ideas and practices concerning illness and healing that have emerged in Buddhist contexts, or that have been embraced and carried by that religion as it has spread throughout Asia and beyond. Interest in exploring the relationship between mind and body, understanding the nature of mental and physical suffering, and overcoming the discomforts of illness goes back to the very origins of Buddhism. Throughout history, Buddhism has been one of the most important contexts for the cross-cultural exchange of diverse currents of medicine. Medicine associated with and carried by Buddhism formed the basis for a number of local healing traditions that are still widely practiced in much of East, Southeast, and Central Asia. Despite the fact that there are numerous similarities among these regional forms, however, Buddhist medicine was never a cohesive or fixed system. Rather, it should be thought of as a dynamic, living tradition with a few core features and much local variation. Local traditions of Buddhist medicine represent unique hybrid combinations of cross-culturally transmitted and indigenous knowledge. In the modern period, such traditions were thoroughly transformed by interactions with Western colonialism, scientific ideas, and new biomedical technologies. In recent decades, traditional, modern, and hybrid forms of medicine continue to be circulated by transnational Buddhist organizations and through the global popularization of Buddhist-inspired therapeutic meditation protocols. Consequently, Buddhism continues today to be an important catalyst for cross-cultural medical exchange, and it continues to exert a significant influence on healthcare practices worldwide.