His date is not quite certain, but 4th century
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Zeugma (mod. Bâlkîs, opposite Bîrecik), in *Syria on the right bank of the *Euphrates at its chief crossing, about 112 km. (70 miles) below *Samosata. Twin colonies Seleuceia (right bank) and Apamea (left bank) were founded by *Seleucus (1) I (PlinHN 5. 86), which came to be known by the generic name Zeugma (‘junction’), and gave Seleucus control of the lower river crossings of the Euphrates. It is possible that Apamea was merely a suburb of Seleuceia. It was here (in 221) that *Antiochus (3) III met his own bride, *Laodice(3), daughter of *Mithradates II of *Pontus, on her journey from Pontus and celebrated the royal wedding (Polyb. 5. 43. 1–4).