Syukuro Manabe was awarded the Nobel Prize in Physics in 2021 for his work on climate modeling. The Prize recognizes an exceptional career that pioneered a new area of the scientific enterprise revealing the power of numerical simulations and methods for advancing scientific discovery and producing new knowledge. Manabe contributed decisively to the creation of the modern scientific discipline of climate science through numerical modeling, stressing clarity of ideas and simplicity of approach. He described in no uncertain terms the role of greenhouse gases in the atmosphere and the impact of changes in the radiation balance of the atmosphere caused by the anthropogenic increase of such gases, and he revealed the role of water vapor in the greenhouse effect. He also understood the importance of including all the components of the climate system (the oceans, sea ice, and land surface) to reach a comprehensive treatment of the mechanisms of climate in a general circulation model, paving the way to the modern earth system models and the establishment of climate modeling as a leading scientific discipline.