In the past 50 years, human activities and climatic variability have caused major environmental changes in the semi-arid Sahelian zone and desertification/degradation of arable lands is of major concern for livelihoods and food security. In the wake of the Sahel droughts in the early 1970s and 1980s, the UN focused on the problem of desertification by organizing the UN Conference on Desertification (UNCOD) in Nairobi in 1976. This fuelled a significant increase in the often alarmist popular accounts of desertification as well as scientific efforts in providing an understanding of the mechanisms involved. The global interest in the subject led to the nomination of desertification as focal point for one of three international environmental conventions: the UN Convention to Combat Desertification (UNCCD), emerging from the Rio conference in 1992. This implied that substantial efforts were made to quantify the extent of desertification and to understand its causes. Desertification is a complex and multi-faceted phenomenon aggravating poverty that can be seen as both a cause and a consequence of land resource depletion. As reflected in its definition adopted by the UNCCD, desertification is “land degradation in arid, semi-arid[,] and dry sub-humid areas resulting from various factors, including climate variation and human activities” (UN, 1992). While desertification was seen as a phenomenon of relevance to drylands globally, the Sahel-Sudan region remained a region of specific interest and a significant amount of scientific efforts have been invested to provide an empirically supported understanding of both climatic and anthropogenic factors involved. Despite decades of intensive research on human–environmental systems in the Sahel, there is no overall consensus about the severity of desertification and the scientific literature is characterized by a range of conflicting observations and interpretations of the environmental conditions in the region. Earth Observation (EO) studies generally show a positive trend in rainfall and vegetation greenness over the last decades for the majority of the Sahel and this has been interpreted as an increase in biomass and contradicts narratives of a vicious cycle of widespread degradation caused by human overuse and climate change. Even though an increase in vegetation greenness, as observed from EO data, can be confirmed by ground observations, long-term assessments of biodiversity at finer spatial scales highlight a negative trend in species diversity in several studies and overall it remains unclear if the observed positive trends provide an environmental improvement with positive effects on people’s livelihood.