Regional models were originally developed to serve weather forecasting and regional process studies. Typical simulations encompass time periods in the order of days or weeks. Thereafter regional models were also used more and more as regional climate models for longer integrations and climate change downscaling. Regional climate modeling or regional dynamic downscaling, which are used interchangeably, developed as its own branch in climate research since the end of the 1990s out of the need to bridge the obvious inconsistencies at the interface of global climate research and climate impact research. The primary aim of regional downscaling is to provide consistent regional climate change scenarios with relevant spatial resolution to serve detailed climate impact assessments. Similar to global climate modeling, the early attempts at regional climate modeling were based on uncoupled atmospheric models or stand-alone ocean models, an approach that is still maintained as the most common on the regional scale. However, this approach has some fundamental limitations, since regional air-sea interaction remains unresolved and regional feedbacks are neglected. This is crucial when assessing climate change impacts in the coastal zone or the regional marine environment. To overcome these limitations, regional climate modeling is currently in a transition from uncoupled regional models into coupled atmosphere-ocean models, leading to fully integrated earth system models. Coupled ice-ocean-atmosphere models have been developed during the last decade and are currently robust and well established on the regional scale. Their added value has been demonstrated for regional climate modeling in marine regions, and the importance of regional air-sea interaction became obvious. Coupled atmosphere-ice-ocean models, but also coupled physical-biogeochemical modeling approaches are increasingly used for the marine realm. First attempts to couple these two approaches together with land surface models are underway. Physical coupled atmosphere-ocean modeling is also developing further and first model configurations resolving wave effects at the atmosphere-ocean interface are now available. These new developments now open up for improved regional assessment under broad consideration of local feedbacks and interactions between the regional atmosphere, cryosphere, hydrosphere, and biosphere.