An orbitally induced increase in summer insolation during the last glacial-interglacial transition enhanced the thermal contrast between land and sea, with land masses heating up compared to the adjacent ocean surface. In North Africa, warmer land surfaces created a low-pressure zone, driving the northward penetration of monsoonal rains originating from the Atlantic Ocean. As a consequence, regions today among the driest of the world were covered by permanent and deep freshwater lakes, some of them being exceptionally large, such as the “Mega” Lake Chad, which covered some 400 000 square kilometers. A dense network of rivers developed. What were the consequences of this climate change on plant distribution and biodiversity? Pollen grains that accumulated over time in lake sediments are useful tools to reconstruct past vegetation assemblages since they are extremely resistant to decay and are produced in great quantities. In addition, their morphological character allows the determination of most plant families and genera. In response to the postglacial humidity increase, tropical taxa that survived as strongly reduced populations during the last glacial period spread widely, shifting latitudes or elevations, expanding population size, or both. In the Saharan desert, pollen of tropical trees (e.g., Celtis) were found in sites located at up to 25°N in southern Libya. In the Equatorial mountains, trees (e.g., Olea and Podocarpus) migrated to higher elevations to form the present-day Afro-montane forests. Patterns of migration were individualistic, with the entire range of some taxa displaced to higher latitudes or shifted from one elevation belt to another. New combinations of climate/environmental conditions allowed the cooccurrences of taxa growing today in separate regions. Such migrational processes and species-overlapping ranges led to a tremendous increase in biodiversity, particularly in the Saharan desert, where more humid-adapted taxa expanded along water courses, lakes, and wetlands, whereas xerophytic populations persisted in drier areas. At the end of the Holocene era, some 2,500 to 4,500 years ago, the majority of sites in tropical Africa recorded a shift to drier conditions, with many lakes and wetlands drying out. The vegetation response to this shift was the overall disruption of the forests and the wide expansion of open landscapes (wooded grasslands, grasslands, and steppes). This environmental crisis created favorable conditions for further plant exploitation and cereal cultivation in the Congo Basin.