Southern Africa extends from the equator to about 34°S and is essentially a narrow, peninsular land mass bordered to its south, west, and east by oceans. Its termination in the mid-ocean subtropics has important consequences for regional climate, since it allows the strongest western boundary current in the world ocean (warm Agulhas Current) to be in close proximity to an intense eastern boundary upwelling current (cold Benguela Current). Unlike other western boundary currents, the Agulhas retroflects south of the land mass and flows back into the South Indian Ocean, thereby leading to a large area of anomalously warm water south of South Africa which may influence storm development over the southern part of the land mass. Two other unique regional ocean features imprint on the climate of southern Africa—the Angola-Benguela Frontal Zone (ABFZ) and the Seychelles-Chagos thermocline ridge (SCTR). The former is important for the development of Benguela Niños and flood events over southwestern Africa, while the SCTR influences Madden-Julian Oscillation and tropical cyclone activity in the western Indian Ocean. In addition to South Atlantic and South Indian Ocean influences, there are climatic implications of the neighboring Southern Ocean. Along with Benguela Niños, the southern African climate is strongly impacted by ENSO and to lesser extent by the Southern Annular Mode (SAM) and sea-surface temperature (SST) dipole events in the Indian and South Atlantic Oceans. The regional land–sea distribution leads to a highly variable climate on a range of scales that is still not well understood due to its complexity and its sensitivity to a number of different drivers. Strong and variable gradients in surface characteristics exist not only in the neighboring oceans but also in several aspects of the land mass, and these all influence the regional climate and its interactions with climate modes of variability. Much of the interior of southern Africa consists of a plateau 1 to 1.5 km high and a narrow coastal belt that is particularly mountainous in South Africa, leading to sharp topographic gradients. The topography is able to influence the track and development of many weather systems, leading to marked gradients in rainfall and vegetation across southern Africa. The presence of the large island of Madagascar, itself a region of strong topographic and rainfall gradients, has consequences for the climate of the mainland by reducing the impact of the moist trade winds on the Mozambique coast and the likelihood of tropical cyclone landfall there. It is also likely that at least some of the relativity aridity of the Limpopo region in northern South Africa/southern Zimbabwe results from the location of Madagascar in the southwestern Indian Ocean. While leading to challenges in understanding its climate variability and change, the complex geography of southern Africa offers a very useful test bed for improving the global models used in many institutions for climate prediction. Thus, research into the relative shortcomings of the models in the southern African region may lead not only to better understanding of southern African climate but also to enhanced capability to predict climate globally.