The effects of uncertainty and anxiety are profiled in association with intercultural communication and the initiation and development of intercultural relationships. Uncertainty is cognitive and refers to what one knows about another and one’s level of predictability about another. Anxiety is the affective equivalent of uncertainty and refers to the level of discomfort associated with interacting with a stranger. Two major theories are associated with this process, including uncertainty reduction theory and anxiety/uncertainty management theory. Other communicative factors also affect uncertainty and anxiety reduction and management during intercultural communication.