Communication has the power to heal and to wound, to tyrannize and to liberate, to enlighten and to deceive, to inspire and to corrupt. Subjecting ideas to the scrutiny of others through engagements of difference has long been recognized as a vital resource for the fulfillment of communication’s constructive potential as well as a critically needed antidote to the corrupting influences associated with demagoguery, confirmation bias, ideological rigidity, and partisanship. Demographic shifts and technological advancements afford unparalleled opportunities for such open, deliberative engagements and related inquiries. Enriched by attentive listening, dialogic communication provides a particularly promising means of tapping these and other resources to reach across differences in pursuit of knowledge, understanding, truth, and wise discernment. Despite their potential, however, listening and dialogue face formidable obstacles. Among these are dominant narratives regarding the human condition, power imbalances, and privilege, and their implications for communication ethics. Absolutism, radical relativism, and related false dilemmas pose significant obstacles as well. A transformation of vision—from individual adversarialism to an ethic of interdependence—offers a pathway out of the thicket, enabling humanity to tap communication’s potential in shared pursuit of human flourishing across the globe.