The Breast Cancer and Environment Research Program (BCERP) is a transdisciplinary program of research created to investigate environmental exposures and their relationship to breast cancer with a particular focus on puberty as a potential window of increased susceptibility to environmental exposures. A transdisciplinary approach has a strong focus on translating scientific findings into usable health practices as well as health prevention messages so that current research informs practice as well as communication to the lay public. BCERP engaged in communication science to develop health messages for lay audiences, health professionals, and outreach organizations. The precautionary principle, used as a primary guide in regards to message translation and dissemination, yields a useful discussion of the BCERP organizational structure. An exploration of formative communication science efforts in BCERP, areas of sensitivity for creating BCERP messages, and resources created for BCERP toolkits serves to illustrate and describe this one approach to designing health and risk messages.