From birth to death, our interactions with others are what inform our identity and give meaning to life. Ultimately, it is interpersonal communication that is the bedrock of wellness. Much of the scholarship on interpersonal communication places communication in the background, characterized merely as a resource, symptom, or contributing factor to change. In the study of our interpersonal experiences, communication must be at the forefront. As a pragmatic lens concerned with real-world issues, a life-span perspective of interpersonal scholarship provides boundless opportunities for bridging science and practice in meaningful ways that improve social life on multiple levels, from families to schools to government to hospitals. Interpersonal communication research that is concerned with life-span issues tends to prioritize communicative phenomena and bring the communication dynamics of our relational lives to the surface. Typically, this scholarship is organized around the various stages or phases of life. In other words, researchers concerned with interpersonal communication often contextualize this behavior based on dimensions of human development and life changes we typically encounter across the life course, those major life experiences from birth to death. Much of that scholarship also centers on how we develop competence in communication across time or how communication competence is critical to our ability to attain relational satisfaction as well as a high psychological and physical quality of life. This research also highlights the influential role of age, human development, and generational differences, recognizing that our place in the life span impacts our goals and needs and that our sociocultural-historical experiences also inform our communication preferences. A life-span perspective of interpersonal communication also encompasses various theoretical paradigms that have been developed within and outside the communication discipline. Collectively, this scholarship helps illustrate the communicative nature of human life across the entire life trajectory.