The economy of territory that became the United States evolved dramatically from ca. 1000 ce to 1776. Before Europeans arrived, the spread of maize agriculture shifted economic practices in Indigenous communities. The arrival of Europeans, starting with the Spanish in the West Indies in 1492, brought wide-ranging change, including the spread of Old World infectious disease and the arrival of land- and resource-hungry migrants. Europeans, eager to extract material wealth, came to rely on the trade in enslaved Africans to produce profitable crops such as tobacco, rice, and sugar, and they maintained connections with Indigenous communities to sustain the fur trade. The declining number of Indigenous peoples, combined with growing numbers of those of European or African origin, altered the demographic profile of North America, particularly in the territory east of the Mississippi River. Over time, Europeans’ consumer choices expanded, though the wealth gap between white colonists grew, as did the economic gap between free colonists, on the one hand, and unfree Black and Native peoples on the other.