Case study researchers have traditionally focused on micro-level analysis of a “bounded” case, yet this approach has come under methodological scrutiny in a world where phenomena are rarely isolated from globalization’s expansive reach. Social science and policy-oriented research in particular are nearly always subject to local and global histories as well as socio-cultural, political, and economic trends. Furthermore, the experience of individuals, organizations, and institutions are often tangled in interconnected webs of influence, such that a case study that does not trace these underlying relationships is likely to be analyzing only the tip of a phenomenological iceberg. Hence critical scholars call for the need to repurpose traditional case study research methods to embrace shifting contextual factors that surround a research project at multiple levels. Comparative case study methods answer this call by making socio-cultural and political analysis an explicit part of the research process. They expand the researcher’s methodological lens by advancing the analysis of processes across three axes: the horizontal (through distinct research sites), the vertical (through scales; e.g., local vs national) and the transversal (over time; e.g., historically). The methodology is particularly useful for social science research and policy studies, where complex interactions between actors and institutions are tied to socio-cultural, political, and economic contexts. Teacher education research is an area where comparative case studies can potentially contribute to policy formulation. Using the example of case study research on teacher education in India, the comparative case study methodology is shown to be an effective research tool. Through insights into the socio-cultural and political context surrounding pedagogical reform, case study research can generate corrective measures to improve policy effectiveness.