Adolescent psychology and mental health needs in China are part of an interdisciplinary area of research. In this area of research, macro and micro processes are closely linked; biological, cultural, and socio-structural influences tightly intertwined; and patterns identified in other societies fall apart due to the impact of powerful societal forces on individual psychology. As a result, there has been a fundamental and long-lasting split between the idea that “Chinese adolescent psychology” should be a distinctive science within China, addressing issues specific to the circumstances of Chinese children and families, and the argument that it should contribute to a universal theory of human development by documenting its applications to Chinese societies. The problem of the first idea lies in its assumption of cultural relativism or the incommensurability of the human experience of growing up in particular sociocultural contexts. In contrast, the problem of the second argument lies in its failure to ask what is “universal,” when a universal theory is applicable to China, and when it may not be. Arguably, adolescents in all cultures carry vulnerabilities and strengths as they go through the process of major biological and psychological transitions. Certain psychosocial needs, such as the needs for self-exploration, quality peer relationship, and continuous guidance and support from adults, are shared by adolescents across the world, albeit through different forms. When their basic needs are neglected by ideology-driven policies and practices that are carried to an extreme extent, youth mental health is seriously threatened. It is important for researchers not only to go beyond the dichotomous view of the field by taking an ecological approach and multidisciplinary perspectives to investigate the salient issues in adolescent psychology and mental health needs in their specific sociocultural context, but also to consider their broader implications for understanding universally relevant questions about success and sacrifice in human and social development.