The rising number of students diagnosed with autism spectrum disorder (ASD) in schools, and the unique characteristics of these students, has led many educators and parents to question the types of programs and strategies that are most effective in supporting them to achieve within school climates and curriculum of the early 21st century. Moreover, educators and parents must sort through the plethora of information and reports of interventions and treatments claiming to treat or cure autism in order to determine what strategies will best support their children or students. A number of studies have focused on determining the evidence base of specific practices for students on the autism spectrum. However, only a few have investigated the applicability of these strategies in inclusive school environments or specifically employed strategies to address academic needs. This has created a research-to-practice gap for educators working with students on the autism spectrum in inclusive school settings. More promising are studies which have highlighted elements of effective practice in education programs. An analysis of this research reveals four principles of best practice for schools and educators working with students on the autism spectrum: provision of a supportive and structured learning environment for staff and students; consistent provision of child-centered and evidence-based curriculum and instruction; multidisciplinary engagement and collaboration; and meaningful communication and collaboration between families and schools. These principles provide a framework for teachers and parents to work alongside students on the autism spectrum to plan, implement and evaluate strategies that can be embedded and implemented in the class program and are effective in supporting the specific needs of individual students on the autism spectrum.