Critical race theory (CRT) is a framework that attends to the prevalence, permanence, and impact of racism embedded within and manifested through the policies, practices, norms, and expectations of U.S. social institutions and how those concepts have differentially impacted the lived experiences of Black and Brown individuals. CRT bore out of the legal studies—complemented by philosophical and sociological fields—and has since been applied to a multitude of disciplines including education. Composed of several tenets or principles, CRT approaches to research, scholarship, and praxis take a structural, systematic, or systemic perspective rather than an individual or isolated perspective. CRT provides scholars and practitioners the ability to acknowledge and challenge structural racism and intersectional forms of oppression as foundational to the perceived and experienced inequities outlined by various constituents. In providing such a perspective, CRT facilitates the opportunity for future ideologies that promote radical and transformative change to systems and structures that perpetuate racial and intersectional-based oppression. STEM education—representing the disciplines of science, technology, engineering, and mathematics from inter- and intradisciplinary perspectives—constitutes the norms, ideologies, beliefs, and practices hallmarked by and within these fields, examined both separately as individual disciplines (e.g., science) and collectively (i.e., STEM). These concepts comprise what is noted as the culture of STEM. Scholarship on STEM education, broadly conceived, discusses the influence and impact of STEM culture across P–20+ education on access, engagement, teaching, and learning. These components are noted through examining student experiences; teachers’ (faculty) engagement, pedagogy, and practice; leadership and administration’s implementation of the aforementioned structures; and the creation and reinforcement of policies that regulate STEM culture. Critical race theoretical approaches to STEM education thus critique how the culture of STEM differentially addresses the needs and desires of various racially minoritized communities in and through STEM disciplines. These critiques are based on the fact that the power to disenfranchise individuals is facilitated by the culture of whiteness embedded within STEM culture, a perspective that is codified and protected by society to favor and privilege White people. CRT in STEM education research tackles the influence and impact of racism and intersectional oppression on racially minoritized individuals in and through STEM by revealing the manifestation and implications of racism and intersectional oppression on racially minoritized individuals’ STEM interactions. CRT in STEM also provides opportunities to reclaim and create space that more appropriately serves racially minoritized individuals through the use of counterstories that center the lived experience of said individuals at the crux of epistemological and ontological understandings, as well as the formation of policies, programs, and other actions. Such conceptions strive to challenge stakeholders within STEM to alter their individual and collective beliefs and perspectives of how and why race is a contending factor for access, engagement, and learning in STEM. These conceptions also strive to challenge stakeholders within STEM to reconfigure STEM structures to redress race-based inequity and oppression.