With the rise in inclusive practices, information on evidence-based practices for teaching learners with mild to moderate disabilities is an important topic. Many professional and government organizations are working to disseminate this information to educators; however, the process can be thwarted by time, resources, training, and implementation of practices. By using multi-tiered systems of support (MTSS) such as response to intervention (RtI) or positive behavior interventions and support (PBIS), schools can assess for, identify, and implement supports for all learners. If a learner continues to encounter challenges, even with high-quality teaching and strategies, then a more intensive intervention may be needed. One schoolwide change would be to use universal design for learning (UDL) to ensure strategies and supports are provided to all learners. Additionally, students may benefit from assistive technology. Teachers can learn about free and commercial evidence-based educational practices to create a safe environment, implement positive behavioral supports, and provide systematic, explicit instruction in academic areas of reading, writing, mathematics, science, and social sciences.