Across the globe, freshwater scarcity is increasing due to overuse, climate change, and population growth. Increasing water security requires sufficient water from diverse water resources. Wastewater can be used as a valuable water resource to improve water security because it is ever-present and usually available throughout the year. However, wastewater is a convoluted solution because the sources of wastewater can vary greatly (e.g., domestic sewage, agricultural runoff, waste from livestock activity, and industrial effluent). Different sources of wastewater can have vastly different pollutants, and mainly times, it is a complex mixture. Therefore, wastewater treatment, unlike drinking water treatment, requires a different treatment strategy. Various wastewater sources can be reused through wastewater reclamation and recycling, and the required water quality varies depending on the targeted purpose (e.g., groundwater recharge, potable water usage, irrigation). One potential solution is employing tailored treatment schemes to fit the purpose. Assorted physical, chemical, and biological treatment technologies have been established or developed for wastewater reclamation and recycle. The advancement of wastewater reclamation technologies has focused on the reduction of energy consumption and the targeted removal of emerging contaminants. Beyond technological challenges, context can be important to consider for reuse due to public perception and local water rights. Since the early 1990s, several global wastewater reclamation examples have overcome challenges and proved the applicability of wastewater reclamation systems. These examples showed that wastewater reclamation can be a promising solution to alleviate water shortages. As water scarcity becomes more widespread, strong global initiatives are needed to make substantial progress for water reclamation and reuse.