Despite millennia of success as hunters and gatherers, some human groups made a monumental transition to agricultural economies and more sedentary lifeways, broadly referred to as the “Neolithic.” This major tipping point in human history first occurred around 12,000 years ago in Southwest Asia and the eastern Mediterranean, where it is also the best documented. Much research has focused on the origins of agriculture, asking questions about why this event occurred after so much success at hunting and gathering. While early investigations concentrated on the economic significance of the Neolithic, studies in the late 20th century and continuing into the early 21st century also address what are perhaps more significant issues related to social, ritual, political, and ecological aspects of the Neolithic. Equally important is a focus on not only why the Neolithic first occurred, but also its consequences. These often are addressed in relation to the subsequent development of so-called civilizations and the environmental and social impacts that these had, but increasingly there are investigations of the consequences of the Neolithic within itself. These consequences refer to Neolithic societies on both the Near Eastern mainlands and adjacent Mediterranean islands. These include not only economic consequences but also ones related to social organization and complexity, trade, and health and disease. What is apparent is that consequential events during the Neolithic were not linear, following a predictable path. For example, there is strong evidence for substantial environmental deterioration during the Neolithic at sites such as ‘Ain Ghazal in Jordan, where adaptive responses may have included divisions of domestic animal and plant resources. However, in Cyprus, where the Neolithic is now known to be as early as it was on the mainlands, evidence is limited for severe ecological degradation throughout the period. Thus, Neolithic consequences must be examined from a broad perspective, considering both successes and failures.