César Moscoso Carrasco (1904–1966), a central figure in Bolivia’s mid-20th-century public health system, wanted to liberate Bolivia from malaria. In a career that spanned three decades, he came close to achieving this goal, but ultimately did not live to see successful eradication. Moscoso was one of the first Bolivian public health specialists in malariology, and was recognized by the World Health Organization for his contributions to the field in 1963. At all stages of his career, he fortuitously aligned himself with the individual or organization that could help him accomplish his professional ambitions and his mission of eradicating malaria in Bolivia. He was the founder and director of the National Anti-Malaria Service in 1929, where he made a name for himself working to halt the spread of malaria in Mizque, in the Cochabamba region. In the 1940s, he secured a position with the Rockefeller Foundation, where he had access to resources beyond the scope of the Bolivian government and an international network of public health specialists. Finally, in the 1950s, he headed the newly formed National Service for Malaria Eradication, which was a Bolivian government initiative supported by international organizations, such as the World Health Organization and the Pan-American Sanitary Bureau. In the 1950s and 1960s, he came the closest to achieving his goal. Unfortunately, he died the same way he lived: fighting a disease, possibly malaria, which he contracted on a visit to Ceylon as a malaria expert and consultant. Moscoso’s life is a window into many aspects of Bolivia’s 20th-century history. First, his life story illustrates both the potential and limitations of the Bolivian healthcare system. Indeed, Moscoso often had to work with international or binational organizations to accomplish the work that he saw as necessary and important. Second, his career shows how political changes in Bolivia impacted healthcare. Since his career spans the Chaco War of 1932–1935, the politically tumultuous 1940s, and the 1952 National Revolution, it provides a personal account of how these events changed healthcare in Bolivia. His story demonstrates the hardships that Bolivian doctors faced as they worked to improve their healthcare system, including low pay, few resources, and little respect from their foreign colleagues.