Far from monolithic, the seven Central American countries—Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, and Panama—each have unique cultural traditions and historical trajectories. Their different geographies, while not deterministic in any facile manner, influenced their development in ways that continue to shape their national characteristics. The cataclysmic 16th-century Spanish Conquest introduced new peoples and cultural traditions to the region. African slaves, primarily from the sub-Saharan region, accompanied the first Spanish ventures, and, later, as the colonies consolidated and grew, peoples of African descent, both enslaved and free, became a part of the area’s economic and cultural landscape. Starting in the late 18th century, African peoples from the Caribbean—whether forcefully exiled or as a result of searching for economic opportunities—traveled to Central America. Despite a contemporary collective historical amnesia that imagines Africans isolated in specific regions, namely the Caribbean coast, peoples of African descent can be found throughout the Central American nations. Rather than addressing each country, a thematic approach that focuses on the Spanish Conquest, slavery, emancipation, the ethnogenesis of African connected cultures, the historical erasure of Africans, and the contributions of peoples of African descent helps to understand the complex ways that peoples of African descent have impacted the history of modern Central America. For far from isolated to small populations along the Caribbean, the African presence can be discerned throughout the region, even in places often perceived as entirely devoid of its influence.