Led by Túpac Amaru, Túpac Katari, Tomás Katari, and others, the pan-Andean uprising from 1780 to 1782 was the largest and most radical indigenous challenge to Spanish colonial rule in the Americas since the conquest. Whole insurgent armies were organized in the heart of Peru and Alto Peru (today Bolivia) over the course of two years. Ancient and populous cities such as Cuzco, La Paz, Chuquisaca, Oruro, and Puno were besieged and occupied. Extensive rural areas in Charcas, the provinces in the high Andean plateau bordering Lake Titicaca, and the southern Peruvian sierras, fell under the complete control of the rebel forces. These forces occasionally relied on the direct support of creoles and mestizos. Although Túpac Amaru, the self-proclaimed new Inca king, would become the primary symbol of the rebellion, the insurgent uprisings combined multiple regional uprisings, each with its own history and dynamic. This article explores the similarities and differences among these uprisings in terms of ethnic ideology, social composition, leadership structure, and insistent demands for change.