Although it has received less scholarly attention than firearms, microbes, domestic animals and plants, market economy, and statecraft, alphabetic reading and writing was crucial in the European conquest and colonization of the Americas from the late 15th century on. Unlike the agrarian empires the Spaniards encountered in the Andes and the Mexican highlands, the Portuguese frontier advanced upon tribal peoples who relied exclusively on oral language, such as the Tupi of Atlantic Brazil. These were semi-sedentary horticultural villagers whose entire socio-ecology (myths and knowledge, territoriality, subsistence strategies, etc.) was conditioned by the face-to-faceness and fugacity of spoken words. In turn, their Portuguese colonizers—for a while rivaled by the French, who enjoyed short periods of stable settlement through the early 17th century—were urban-based, oceangoing merchants, bureaucrats, soldiers, and religious missionaries whose organization strictly depended on the durability and transferability of written texts. Even if most of the Portuguese who came to Brazil in the 16th century were themselves illiterate, colonization as a social enterprise framed their actions according to prescribed roles set down in writing (both handwriting and printed script). Thus, the Portuguese colonization of Brazilian native lands and human populations can be interpreted from the point of view of the imposition of an alphabetically organized way of life. Two major dimensions of this “letterscaping” can be discerned as to its impact on Amerindian bodies (human and nonhuman) and modes of understanding. Although the 16th century was only the introductory act in that drama, its historical record shows the basic outlines of the alphabetic colonization that would play out through the early 19th century: native decimation and enslavement, territory usurpation by sesmaria grants, forest recovery in former native croplands (then resignified as “virgin forest”), loss of native ecological knowledge not recorded in writing, disempowerment of native cultural attunement to the wild soundscape, among other processes.