Although Freud’s key claims regarding unconscious processes are pervasive in psychoanalytic theory, psychoanalysis is not a singular unified system. Early originating frameworks have evolved to adapt to changing clinical practices. In Britain, Freud’s work was complicated by the work of Klein, and later by the British Object Relations school, and still later by the inclusion of empirical research from John Bowlby’s attachment theory. In France and Latin America, Lacan gained dominance; in the United States, early work in “ego psychology” was supplemented by Kohutian “self-psychology” and later by “relational psychoanalysis.” In the academy, the work of Slavoj Zizek, synthesizing Lacanian and Marxist theory, has had wide influence. All these perspectives offer different accounts of the legacies of the past in their impact on unconscious expression. Early applications of psychoanalysis to literature were concerned with the origins of creativity and the neurotic conditions of literary characters or authors. Subsequent interests have focused on the nature of literary language and the dynamics of readerly engagements. In the early 21st century, use of psychoanalysis as an analytic tool follows the model of a conversation. The goal is not to apply a theory to a text to illustrate a psychoanalytic truth but to tease out the “unsaid” of a text or set of texts. Psychoanalysis in literary engagements, as in clinical engagements, is not about establishing a truth; instead it is used in “dialogue” with another discourse to discover implicit or unacknowledged dimensions of that articulation. The diversity of psychoanalytic schools and concepts allows scholars to give attention to wide-ranging interests: to the grip of ideology on subject, to the unconscious thematics of authors, to the symptomatic conditions of culture. Popular subjects for the psychoanalytic study of literature or film are psychic conflict, suffering, anxiety, enjoyment, the uncanny, and the repressed. Following World War II, the Frankfurt school synthesized Freud with Marxist thought, laying out enduring parameters for the psychoanalytic study of social processes. Adorno and Horkheimer sought to understand totalitarian character and mass culture and explored literature as a response to ideological enlistment. Recent work by “the Lacanian Left” in political theory explores libidinal and affective dimensions of discourse. “Psychosocial studies” scholars in Britain utilize psychoanalytic principles to gain more complex information from interviews and social research designs. Contemporary work in neuropsychoanalysis develops empirical evidence to document psychoanalytic processes in the organizational patterns of the brain, particularly in the dynamics of dreaming, memory, and nonconscious behavior. All these newly emerging engagements with psychoanalytic thought offer opportunities for contemporary research.