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Animals have prowled literature from its beginnings in the ancient world through medieval bestiaries and out from the margins of the novel in the modern era. In the late 20th and early 21st centuries, animals’ literary presence has generated increasing critical interest. Animal studies, a relatively new interdisciplinary field, calls attention to the accelerating exploitation of animals in the period of industrial modernity and questions what it is possible to know about animals’ own experiences. Foundational theoretical approaches to understanding the historical and philosophical condition of thinking about animals—John Berger’s “Why Look at Animals?” (1972), Thomas Nagel’s “What Is It Like to Be a Bat?” (1974), and Jacques Derrida’s “The Animal That Therefore I Am (More to Follow)” (2002)—propose a fundamental aporia or gap between human and animal experiences, and they caution against the projection of anthropocentric categories onto animal lives. Many novels from this recent period likewise treat animals as charismatic strangers. Yet other contemporary literature sometimes reimagines human-animal relationships to insist on affinity and continuity. In such novels, animals prompt diverse and often experimental stylistic choices that put pressure on the novel’s traditional association with everyday life, the individual self, the boundaries of the nation, and empirical observation more broadly. Still, many recent novels remain essentially committed to a realist tradition. Some of these—most notably by J. M. Coetzee—depict relations of care between humans and often vulnerable or dependent animals that prompt reflection on the meaning of ethical action. In novels that purport to narrate from animals’ own perspective, writers likewise meditate on the ethics of interspecies relations as they use language innovatively in an effort to realistically evoke the sensorium of another species. Pushing the boundaries of realism, other novels reinvent the animal fable, using varying degrees of fantasy to imagine wild or domesticated animals as tropes that reflect upon human embodiment, community, and politics. Whether realist or fabulist, the novels of contemporary postcolonial and world literature particularly explore the power and limits of mapping histories of human belonging and domination onto animal figures, even as they often highlight the limitations of these comparisons. Not all of these approaches are equally invested in creating a literature that could materially impact the lives of animals in an era of diminishing biodiversity. However, uniting this varied and ever-growing array of novels is a question of how literature can represent the lives of intimately entangled bodies in a globalizing world.