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Disability—whether physical, mental, or sensory—is widely represented in Early Modern literature, and as such it has been attracting attention from 21st-century literary scholars, who apply the theoretical and critical tools of disability studies to Renaissance narratives and literary characters. Literary disability in its various forms can be analyzed in the light of various models of disability, including medical, social, moral, or cultural. This helps in understanding early modern representations and experiences of disability in culture and history and making sense of reactions to disability in the period: including stigma, mockery, proud identification with the disabled identity, or also a desire for it. Physical disabilities in the Renaissance encompass anything from deformity to bodily mutilation to dwarfism or monstrosity, and they are especially prone to be emphasized, explained, or scrutinized in search of their meaning. Sensory disabilities, including blindness, deafness, and mutism, prompt interpretations that connect physical impairment with the character’s inability or surprising ability to understand reality—whether in a pragmatic or spiritual sense. Intellectual and mental disabilities have many ramifications in early modern literature, some of which, such as fools and madmen, are staple types of drama. Intellectual and mental disabilities are often described in medical terms, but literary texts tend to differentiate between them, whether in technical or narrative terms. Foolishness normally turns into comedy, whereas madness is often connected with tragic characters undergoing mental breakdowns. Renaissance disability studies are also concerned with less obvious types of disability: disabilities that were disabilities in the past but not in the 21st century, concealed disabilities, and disabilities that are not actually disabilities but do foster a conversation that excludes the character who does not embody what society regarded as the ideal physical shape. Finally, instances of counterfeited disability and disability attached to concepts rather than people help understand how Renaissance culture often viewed the nonstandard body not only as something to beware of or reject but also as an image of empowerment.