The question of indigeneity in the study of Latina/o literature and culture points toward conflictive histories of colonization and invigorates a set of global directions for the future of Latina/o studies. The pairing of the two terms—Latina/o and Indigeneity—appears initially counterintuitive. Conventionally understood as an ancestral relation of Latina/o communities that has been vanished or lost over the duration of the European colonization of the Americas, Indigeneity opens a set of insuperable problematics that continue to pattern and shape multiple and incommensurate iterations of Latina/o politics and culture. While “Latina/o” in some instances denotes ancestral relation with Native tribes in the Americas, for many the term has also come to signify decidedly non-indigenous mestiza/o, settler, or migrant identities, imaginaries, and belongings. The literary, cultural, and intellectual production of Latina/o Indigeneity offers a unique window into the ways in which Native politics continue to compete with, accommodate, and challenge multiple regimes of colonial occupation and periods of modern state formation. Indigeneity illuminates places of Latina/o literary and cultural production through which to engage the historic ascendance of a number of fundaments of modern life across the globe, including capitalism, nation-state sovereignty, and the transnational social structures of race, sex, citizenship, and gender.