Though “literature and science” has denoted many distinct cultural debates and critical practices, the historicist investigation of literary-scientific relations is of particular interest because of its ambivalence toward theorization. Some accounts have suggested that the work of Bruno Latour supplies a necessary theoretical framework. An examination of the history of critical practice demonstrates that many concepts presently attributed to or associated with Latour have been longer established in the field. Early critical work, exemplified by Marjorie Hope Nicolson, tended to focus one-sidedly on the impact of science on literature. Later work, drawing on Thomas Kuhn’s idea of paradigm shifts, and on Mary Hesse’s and Max Black’s work on metaphor and analogy in science, identified the scope for a cultural influence on science. It was further bolstered by the “strong program” in the sociology of scientific knowledge, especially the work of Barry Barnes and David Bloor. It found ways of reading scientific texts for the traces of the cultural, and literary texts for traces of science; the method is implicitly modeled on psychoanalysis. Bruno Latour’s accounts of literary inscription, black boxing, and the problem of explanation have precedents in the critical practices of critics in the field of literature and science from the 1980s onward.