With a continuous global increase in flood frequency and intensity, there is an immediate need for new science-based solutions for flood mitigation, resilience, and adaptation that can be quickly deployed in any flood-prone area. An integral part of these solutions is the availability of river discharge measurements delivered in real time with high spatiotemporal density and over large-scale areas. Stream stages and the associated discharges are the most perceivable variables of the water cycle and the ones that eventually determine the levels of hazard during floods. Consequently, the availability of discharge records (a.k.a. streamflows) is paramount for flood-risk management because they provide actionable information for organizing the activities before, during, and after floods, and they supply the data for planning and designing floodplain infrastructure. Moreover, the discharge records represent the ground-truth data for developing and continuously improving the accuracy of the hydrologic models used for forecasting streamflows. Acquiring discharge data for streams is critically important not only for flood forecasting and monitoring but also for many other practical uses, such as monitoring water abstractions for supporting decisions in various socioeconomic activities (from agriculture to industry, transportation, and recreation) and for ensuring healthy ecological flows. All these activities require knowledge of past, current, and future flows in rivers and streams. Given its importance, an ability to measure the flow in channels has preoccupied water users for millennia. Starting with the simplest volumetric methods to estimate flows, the measurement of discharge has evolved through continued innovation to sophisticated methods so that today we can continuously acquire and communicate the data in real time. There is no essential difference between the instruments and methods used to acquire streamflow data during normal conditions versus during floods. The measurements during floods are, however, complex, hazardous, and of limited accuracy compared with those acquired during normal flows. The essential differences in the configuration and operation of the instruments and methods for discharge estimation stem from the type of measurements they acquire—that is, discrete and autonomous measurements (i.e., measurements that can be taken any time any place) and those acquired continuously (i.e., estimates based on indirect methods developed for fixed locations). Regardless of the measurement situation and approach, the main concern of the data providers for flooding (as well as for other areas of water resource management) is the timely delivery of accurate discharge data at flood-prone locations across river basins.