This chapter analyzes the impacts of climate change on flood factors and extent of associated damages in the Hindu Kush (HK) region. HK mountains system is located in the west of the Himalayas and Karakorum. It is the greatest watershed of the River Kabul, River Chitral, River Panjkora, and River Swat in the eastern Hindu Kush and River Amu in western Hindu Kush. The Hindu Kush system hosts numerous glaciers, snow-clad mountains, and fertile river valleys; it also supports large populations and provides year-round water to recharge streams and rivers. The study region is vulnerable to a wide range of hazards including floods, earthquakes, landslides, desertification, and drought. Flash floods and riverine floods are the deadliest extreme hydro-meteorological events. The upper reaches experience characteristics of flash flooding, whereas the lower reach is where river floods occur. Flash floods are more destructive and sudden. Almost every year in summer, monsoonal rainfall and high temperature join hands with heavy melting of glaciers and snow accelerating discharge in the river system. In the face of climate change, a significant correlation between rainfall patterns, trends in temperature, and resultant peaks in river discharge have been recorded. A rising trend was found in temperature, which leads to early and rapid melting of glaciers and snow in the headwater region. The analysis reveals that during the past three decades, radical changes in the behavior of numerous valley glaciers have been noted. In addition, the spatial and temporal scales of violent weather events have been growing, since the 1980s. Such changes in water regimes including the frequent but substantial increase in heavy precipitation events and rapid melting of snow in the headwater region, siltation in active channels, excessive deforestation, and human encroachments onto the active flood channel have further escalated the flooding events. The HK region is beyond the reach of existing weather RADAR network, and hence forecasting and early warning is ineffective. Here, almost every year, the floods cause damages to infrastructure, scarce farmland, and sources of livelihood.