Despite myriad descriptions and indicators used to define a fragile state, the international community has come to an agreement that a fragile state lacks the ability to maintain physical control of its territorial boundaries, provide basic public services, facilitate economic growth, and interact as a full member of the international community. Fragile states have historically experienced a disproportionate amount of natural disaster-related losses. For example, from 2005 to 2009, more than 50% of those impacted by a natural disaster lived in a fragile state, resulting in over $200 billion in losses. When natural disasters occur in such areas, they exacerbate already weak governance structures and further undermine their governments’ capability to respond to the crisis while simultaneously addressing challenges related to poverty and conflict. To remedy these and other complex issues inherent in fragile states, scholars are beginning to recognize the importance of investigating how fragile states can mitigate natural disaster losses through effective agency coordination and cross-sector collaboration. Agency coordination, in the context of natural disaster response, refers to the integration of facilities, equipment, personnel, and communication by public agencies for supporting incident response activities. Cross-sector collaboration refers to the sharing of information and resources by organizations in two or more sectors to achieve an outcome that cannot be produced by organizations in one sector alone. Because forecasts suggest that natural disaster-related losses will only increase in fragile states owing to population growth, urbanization, and climate change, there is a pressing need to understand the ways public organizations not only coordinate before, during, and after a natural disaster, but also how they collaborate across organizational sectors.