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date: 30 November 2022

Network Analyses and Nervous System Disorderslocked

Network Analyses and Nervous System Disorderslocked

  • John D. MedagliaJohn D. MedagliaDepartment of Psychology, Drexel University and Department of Neurology, University of Pennsylvania
  •  and Danielle S. BassettDanielle S. BassettDepartment of Bioengineering and Department of Electrical and Systems Engineering, University of Pennsylvania


Network analyses in nervous system disorders involve constructing and analyzing anatomical and functional brain networks from neuroimaging data to describe and predict the clinical syndromes that result from neuropathology. A network view of neurological disease and clinical syndromes facilitates accurate quantitative characterizations and mathematical models of complex nervous system disorders with relatively simple tools drawn from the field of graph theory. Networks are predominantly constructed from in vivo data acquired using physiological and neuroimaging techniques at the macroscale of nervous system organization. Studies support the emerging view that neuropsychiatric and neurological disorders result from pathological processes that disrupt the brain’s economically wired small-world organization. The lens of network science offers theoretical insight into progressive neurodegeneration, neuropsychological dysfunction, and potential anatomical targets for interventions ranging from pharmacological agents to brain stimulation.


  • Computational Neuroscience
  • Disorders of the Nervous System

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