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date: 29 September 2023

Nicotinic Acetylcholine Receptors and Affective Responseslocked

Nicotinic Acetylcholine Receptors and Affective Responseslocked

  • Kalynn Schulz, Kalynn SchulzUniversity of Tennessee Knoxville - Psychology
  • Marcia ChavezMarcia ChavezUniversity of Tennessee Knoxville - Psychology
  •  and Arthur CastanedaArthur CastanedaUniversity of Tennessee Knoxville - Psychology


Nicotinic acetylcholine receptors (nAChRs) are present throughout the central nervous system and involved in a variety of physiological and behavioral functions. Nicotinic acetylcholine receptors are receptive to the presence of nicotine and acetylcholine and can be modulated through a variety of agonist and antagonist actions. These receptors are complex in their structure and function, and they are composed of multiple α and β subunits. Many affective disorders have etiological links with developmental exposure to the nAChR agonist nicotine. Given that abnormalities in nAChRs are associated with affective disorders such as depression and anxiety, pharmacological interventions targeting nAChRs may have significant therapeutic benefits.


  • Development
  • Disorders of the Nervous System
  • Neuroendocrine and Autonomic Systems

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