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Gut Dysbiosis and Recovery of Function After Spinal Cord Injury  

Kristina A. Kigerl and Phillip G. Popovich

Online publication date:
Jul 2019
Spinal cord injury (SCI) disrupts the autonomic nervous system (ANS) and impairs communication with organ systems throughout the body, resulting in chronic multi-organ pathology and ... More

Enhancing the Regeneration of Neurons in the Central Nervous System  

Romain Cartoni, Frank Bradke, and Zhigang He

Online publication date:
Feb 2019
Injured axons fail to regenerate in the adult mammalian central nervous system, representing a major barrier for effective neural repair. Both extrinsic inhibitory environments and ... More

The Hypocretin Arousal Network  

Jeremy C. Borniger and Luis de Lecea

The hypocretins (also known as orexins) are selectively expressed in a subset of lateral hypothalamic neurons. Since the reports of their discovery in 1998, they have been intensely ... More

Mechanisms of Behavioral Changes After Spinal Cord Injury  

Karim Fouad, Abel Torres-Espín, and Keith K. Fenrich

Online publication date:
Jan 2019
Spinal cord injury results in a wide range of behavioral changes including impaired motor and sensory function, autonomic dysfunction, spasticity, and depression. Currently, restoring lost ... More

Network Analyses and Nervous System Disorders  

John D. Medaglia and Danielle S. Bassett

Online publication date:
Sep 2018
Network analyses in nervous system disorders involve constructing and analyzing anatomical and functional brain networks from neuroimaging data to describe and predict the clinical ... More

Plasticity in the Regenerating Nervous System of the Lamprey, a “Simple” Vertebrate  

William Rodemer, Jianli Hu, and Michael E. Selzer

Online publication date:
Feb 2018
Human spinal cord injury (SCI) results in long-lasting disabilities due to the failure of damaged neurons to regenerate. The barriers to axon regeneration in mammalian central nervous ... More

Using Neural Stem Cells to Enhance Repair and Recovery of Spinal Circuits After Injury  

Itzhak Fischer and Shaoping Hou

Spinal cord injury is characterized by a complex set of events, which include the disruption of connectivity between the brain and the periphery with little or no spontaneous regeneration, ... More

Neuroimmunology: Behavioral Effects  

Gretchen N. Neigh, Mandakh Bekhbat, and Sydney A. Rowson

Bidirectional interactions between the immune system and central nervous system have been acknowledged for centuries. Over the past 100 years, pioneering studies in both animal models and ... More

Developmental Neurobiology of Anxiety and Related Disorders  

Emily M. Cohodes and Dylan G. Gee

Online publication date:
Dec 2017
The majority of anxiety disorders emerge during childhood and adolescence, a developmental period characterized by dynamic changes in frontolimbic circuitry. Frontolimbic circuitry plays a ... More

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