Enhancing the Regeneration of Neurons in the Central Nervous System
- Romain Cartoni, Romain CartoniDuke University, Department of Pharmacology and Cancer Biology
- Frank BradkeFrank BradkeResearch Group on Axon Growth and Regeneration, German Center for Neurodegenerative Diseases
- and Zhigang HeZhigang HeDepartment of Neurology, Boston Children's Hospital
Injured axons fail to regenerate in the adult mammalian central nervous system, representing a major barrier for effective neural repair. Both extrinsic inhibitory environments and neuron-intrinsic mechanisms contribute to such regeneration failure. In the past decade, there has been an explosion in our understanding of neuronal injury responses and regeneration regulations. As a result, several strategies have been developed to promote axon regeneration with the potential of restoring functions after injury. This article will highlight these new developments, with an emphasis on cellular and molecular mechanisms from a neuron-centric perspective, and discuss the challenges to be addressed toward developing effective functional restoration strategies.