Earth’s moon, hereafter referred to as “the Moon,” has been an object of intense study since before the time of the Apollo and Luna missions to the lunar surface and associated sample returns. As a differentiated rocky body and as Earth’s companion in the solar system, much study has been given to aspects such as the Moon’s surface characteristics, composition, interior, geologic history, origin, and what it records about the early history of the Earth-Moon system and the evolution of differentiated rocky bodies in the solar system. Much of the Apollo and post-Apollo knowledge came from surface geologic exploration, remote sensing, and extensive studies of the lunar samples. After a hiatus of nearly two decades following the end of Apollo and Luna missions, a new era of lunar exploration began with a series of orbital missions, including missions designed to prepare the way for longer duration human use and further exploration of the Moon. Participation in these missions has become international. The more recent missions have provided global context and have investigated composition, mineralogy, topography, gravity, tectonics, thermal evolution of the interior, thermal and radiation environments at the surface, exosphere composition and phenomena, and characteristics of the poles with their permanently shaded cold-trap environments. New samples were recognized as a class of achondrite meteorites, shown through geochemical and mineralogical similarities to have originated on the Moon. New sample-based studies with ever-improving analytical techniques and approaches have also led to significant discoveries such as the determination of volatile contents, including intrinsic H contents of lunar minerals and glasses. The Moon preserves a record of the impact history of the solar system, and new developments in timing of events, sample based and model based, are leading to a new reckoning of planetary chronology and the events that occurred in the early solar system. The new data provide the grist to test models of formation of the Moon and its early differentiation, and its thermal and volcanic evolution. Thought to have been born of a giant impact into early Earth, new data are providing key constraints on timing and process. The new data are also being used to test hypotheses and work out details such as for the magma ocean concept, the possible existence of an early magnetic field generated by a core dynamo, the effects of intense asteroidal and cometary bombardment during the first 500 million–600 million years, sequestration of volatile compounds at the poles, volcanism through time, including new information about the youngest volcanism on the Moon, and the formation and degradation processes of impact craters, so well preserved on the Moon. The Moon is a natural laboratory and cornerstone for understanding many processes operating in the space environment of the Earth and Moon, now and in the past, and of the geologic processes that have affected the planets through time. The Moon is a destination for further human exploration and activity, including use of valuable resources in space. It behooves humanity to learn as much about Earth’s nearest neighbor in space as possible.