Media are key for the functioning of democracy. It is the essential link between politics and citizens, providing critical information and interpretation of politics and room for debate. Given this central role of the media for democratic political processes, questions about how mediated political information would affect citizens’ perceptions of and attitudes toward politics, as well as ultimately political behavior, have been dominant in research in the field of political communication. While vast amounts of mid-range theories and empirical insights speak in favor of influences of media on citizens, there is little in terms of a universal theoretical framework guiding political media effects research, which makes it difficult to give a conclusive answer to the question: how and, in particular, how much do the media matter? It may matter for some people under some conditions in some contexts relating to some outcome variables. Technological changes in media systems pose additional challenges, both conceptually and methodologically, to come to comprehensive assessments of media influences on citizens’ political cognitions, attitudes, or behaviors. Research needs to be clearer as to which conceptualization of media is followed and how such conceptualization may interact with other dimensions of media attributes. Measurement of media use and reception needs to take into account the increasing complexities of how citizens encounter political information, and it requires alignment with the conceptualization of media. Political media effect theories should not continue developing side by side, but should attempt to find a place in a more comprehensive model and take into account how they relate to and possibly interact with other approaches. In sum, the field of political media effects, while vast and covering a range of aspects, would do well to consider its role and purpose in increasingly complex media environments and, accordingly, provide more integrative perspectives, conceptually, methodologically, and theoretically.