Historically, the Catholic Church in Latin America has supported conservative interests. It legitimized Spanish colonial rule and sided with traditionalist elites following Latin American independence. However, beginning in the mid-20th century, some within the Church engaged with social causes, and a new progressive theology inspired many priests and bishops to advocate politically on behalf of the poor. The resultant movement helped topple dictatorships, facilitated transitions to democracy, and developed as a result of three factors. First, liberation theology emboldened clergy to support the political causes of the poor and created an ideological frame encouraging Catholic laity to organize for social change. Furthermore, competition from new Protestant religions provided Catholic leadership with an incentive to support secular political movements and created an opportunity for political engagement through the Catholic Church. Finally, decentralization within the Church encouraged Catholic adherents to engage and develop organizational capacities at the grass-roots. Taken together, scholarly explanations emphasizing framing, opportunity, and resource mobilization create a compelling account of the development of progressive Catholic activism. Less sustained theoretical attention has been given to assessing the dynamics of conservative Latin American Catholic advocacy. The Church consistently opposes abortion, divorce, the use of contraceptives, and gay marriage. Moreover, although the Catholic Church has enabled many women’s political movements, it suppresses efforts at liberalizing reproductive rights. Future research on Catholic advocacy in Latin America should identify additional pathways through which framing, opportunity, and resource mobilization influence conservative Catholic advocacy in the region. Additionally, the Church’s relationship with environmental issues is understudied. Finally, Latin America offers untapped potential to examine the complicated relationship between ethnicity, religion, and collective action.