One-quarter of the world’s states are African and can contribute to international relations theory and practice as the North enters a period of ambivalence and begins to retreat from positive global engagement. Each actor based in or concerned about the African continent, state and non-state alike, advances a foreign policy to reflect its interests, often in coalition with others. East-South relations and a non-Western world, as well as Brazil, Russia, China, India, and South Africa, are important in international development and emerging powers in Africa. The diversion away from international order and peace of the United States under President Donald Trump, the United Kingdom under Prime Minister Theresa May, and the European Union, the latter characterized by unanticipated immigration and endless Eurozone crises, can be positive for African agency and development if the continent can seize the unprecedented space to advance its own developmental states and regionalisms. Such possibilities of Africa’s enhanced prospects are situated in terms of a changing global political economy in which new economies, companies, and technologies are emerging along with contrary, nontraditional security threats. In response, novel forms of transnational “network” governance are being conceived and charted to advance sustainable developmental states and regionalisms through innovative foreign policy stances outside established, but increasingly dysfunctional and ossified, interstate institutions.