The cultural distinctiveness of the South led to a backlash in the region in the years following the rise of a national LGBTQ movement. In the decades that followed, political science research showed that the South remained fundamentally different than elsewhere in the nation in terms of attitudes regarding LGBTQ individuals and policies, both regarding overall views and Southerners’ imperviousness to personal contact with queer individuals in terms of reshaping attitudes. In electoral politics, explicit group-based appeals regarding LGBTQ individuals were often employed. And, policy divergence between the South and non-South was stark. While unambiguous shifts have occurred in the South in a more pro-LGBTQ rights direction, the region remains distinctively conservative when it comes to LGBTQ politics. Particularly striking are Southern attitudes toward transgender individuals and policies. That said, “two Souths” have begun to cement on LGBTQ politics as urbanized and suburbanized areas have diverged. Moreover, within the region’s Republican Party, a factional divide has begun to show itself across the South. The South remains consequential in gauging whether backpedaling on the dramatic progress made on LGBTQ rights is occurring in the United States.