If Latin American and Caribbean integration arose from the interests of nation-state institutions, linked to an international context where commerce and the global market was the mainframe of the economic development theory, some state and academic actors sought to expand the autonomy of nation-states in negotiating trade agreements and treaties under the paradigm of an autonomous governance of regionalism and economic integration. The autonomous integration initiatives arose between the 1960s and 1980s, before neoliberalism emerged as the sole model of development. However, since the 1990s, neoliberal policies have left little room for autonomous integration. A new period of autonomous integration emerged between the late 1990s and 2015, supported by progressive Latin American governments, along with a novel projection of social autonomy, complementary to autonomous integration, held by new social movements that oppose, resist, and create alternatives to neoliberal integration. Inspired by the critical theory, the research linkages between the state and social autonomy question the neoliberal integration process, its perverted effects on exclusion and social inequality, and the conflicts related to the regional integration of democratic governance. The debates on autonomous regional integration cover three fields: economic interdependence, the realist perspective in international politics, and the theses of the field of International Political Economy. Arguments question their critique of the colonial outcomes of the modern world system, even more so than had been posited by dependency theory. Finally, there is the question of the emergence of an original Latin American and Caribbean theory of autonomous integration initiatives.