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Constitutions have been an important part of Latin America’s history since independence. While exhibiting frequent change, there have been continuities primarily regarding their republican form and presidentialism. Extensive scholarship exists on the origins of constitutions, their evolving design, and their effects concerning democratic stability and rights, particularly with regard to trends and patterns since the third wave of democratization in the late 1970s. Large-scale “refounding” constitutional reforms have gained traction with citizens and civil society groups, and populist leaders have promoted them as a solution for socioeconomic and political exclusion. Politicians have also favored both large- and small-scale changes as ways to continue in office, concentrate power, gain or maintain support, or defuse crises. With frequent changes and longer and more complex texts, sharp distinctions between constitutional moments defining the rules and ordinary politics occurring within the rules have blurred. The research on these issues regarding constitutions confronts challenges common to the analysis of weak institutions in general, including particularly endogeneity to existing power distributions in society and thus seeking to understand when and why key actors respect constitutional rules of the game. Some scholarship advances actor-centered linkage arguments connecting the origin, design, and effects of constitutions in a causal progression, on topics such as presidential powers, unequal democracies emerging from authoritarian regimes, or judicial independence. These arguments differ regarding the direct impact they ascribe to constitutions compared to other factors, particularly with more extended time horizons. They typically examine the narrow strategic interests of the key players while also considering when they may contemplate broader goals, especially when no one player is dominant. Though diffusion has played a role in constitutional process and design in the region, most scholars downplay its relative importance. Since the 1990s, there has been a significant expansion in a unidirectional, path-dependent fashion in the incorporation of social, economic, and cultural rights, as well as decentralization and participatory mechanisms. Unlike presidential re-election and presidential powers, which have seen more frequent and sometimes mixed evolution, once these rights and mechanisms are granted they are not formally reversed in subsequent reforms. Yet, their effective realization has been partial and uneven, typically requiring some combination of societal mobilization and institutional activation. Thus, other endogenous or exogenous factors are typically incorporated into explanations regarding their possible effects. Future research in many areas of constitutionalism could be enhanced by a more systematic cross-national multidimensional data collection effort, facilitating further quantitative and multi-methods empirical work. This will assist scholars in addressing the theoretical and methodological challenges in this field common to institutional research generally. At the same time, it is critical not to lose sight of the normative dimension of constitutionalism, given its symbolic and aspirational value as well as practical importance for democracy.